Skip to main content
. Author manuscript; available in PMC: 2007 Nov 19.
Published in final edited form as: J Biol Chem. 2007 Feb 20;282(18):13648–13655. doi: 10.1074/jbc.M611711200

FIGURE 5. Expanded binding pocket for CPA in the AR.

FIGURE 5

a, comparison of the binding pockets in AR LBD complexes demonstrates the increased binding cavity utilized by S-1 (marine) in comparison to DHT (purple). CPA binds the AR (green) to occupy an additional region located in the opposite direction as the expanded S-1 binding pocket. b, the additional binding regions in the AR are due to the induced fit of S-1 and CPA, which displace Trp-741 and Leu-701, respectively. c, Ser-778 in the distant region of the CPA binding pocket provides a potential hydrogen bond partner that may be exploited in designing new ligands for the AR.