Table 1.

Antibody Transport Rates into Various Brain Regions in CD-1 and SAMP8 mice. Ki (± SE of the mean) and p values for significant relations between brain/serum ratios and exposure time. n = number of mice on which analysis is based. OB= olfactory bulb; Hippo= Hippocampus; WBr = Whole Brain. NS = nonsignificant

Antibody L11.3
Strain	Region	Ki (µl/g-min)	p value	n
CD-1	OB	0.0686 ± 0.0314	0.048	15
	Hippo	0.0660 ± 0.0082	<0.0001	14
	W Br	0.0118 ± 0.0052	0.036	20
SAM 4mo	OB		NS
	Hippo	0.0558 ± 0.014	0.0019	13
	W Br	0.0231 ± 0.0099	0.0367	15
SAM 12 mo	OB	0.106 ± 0.0478	0.047	14
	Hippo	0.0714 ± 0.0290	0.0316	13
	W Br	0.0253 ± 0.0098	0.0205	17
Antibody HYL5
Strain	Region	Ki (µl/g-min)	p value	n
CD-1	OB	0.074 ± 0.028	.026	12
	Hippo		NS
	W Br		NS
SAM 4mo	OB		NS
	Hippo	0.0295 ± 0.011	0.0204	13
	W Br		NS
SAM 12 mo	OB		NS
	Hippo		NS
	W Br		NS