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. Author manuscript; available in PMC: 2008 Oct 26.
Published in final edited form as: J Mol Biol. 2007 Aug 22;373(3):652–663. doi: 10.1016/j.jmb.2007.08.033

Figure 1.

Figure 1

Two secondary structure models for the SIV RNA frameshift-inducing element. The seven nucleotide slippery sequence is underlined in each model. (A) Previously proposed stem-loop model.2 (B) Proposed pseudoknot model.16,17 (C-E). RNA constructs studied by NMR. (C). SIV14−70, encompassing nucleotides 14−70 downstream of the slippery site. (D). SIV17−70. The first two C-G base-pairs were flipped to G-C pairs to facilitate in vitro transcription, and are shown in outline. Note that no base pairs are indicated within the pseudoknot portions of the secondary structures in (C) and (D), since the pseudoknot interaction has not been proven and is one of the subjects of this study. (E). SIV17−50. The first two base-pairs are as in (D).