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. 2007 Nov 19;179(4):761–775. doi: 10.1083/jcb.200705002

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — mmvvee embryonic heart has a thin endocardium. (A) mmvvee embryonic hearts are not hypertrophic. Cardiac chambers are not dilated and have normal patterns of trabeculation as shown by hematoxylin and eosin staining of histological sections. Electron microscopy demonstrates formation of Z lines (B, arrows) and intercalated discs (C) in mmvvee embryos. Magnified images of intercalated discs identified by red rectangles are shown under C. (D) The endocardial lining (arrowheads) of mmvvee embryonic hearts are thinner than littermate controls and are less closely associated with the underlying cardiac myocytes (arrows).