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. 2007 Nov 19;179(4):761–775. doi: 10.1083/jcb.200705002

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — Vascular formation and patterning in mmvvee embryos. (A) E10.5 embryos after whole-mount immunohistochemistry with anti-PECAM antibodies. Major blood vessels are present and intact in the mmvvee embryo. (B) Intersomitic vessels appear normal in mmvvee embryos (arrowheads) but there is a reduction in connectivity between them (arrows). (C) The vascular plexus in the mmvvee tail (indicated by brackets and magnified under C) exhibits irregular patterning. Images were gamma adjusted. Major vessels in the amniotic sac (D) and body (E) of mmvvee embryos appear normal in formation and patterning at E16.5. Note the increased volume and turbidity of the mmvvee amniotic fluid.