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. 2007 Nov 19;179(4):761–775. doi: 10.1083/jcb.200705002

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Copyright © 2007, The Rockefeller University Press

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Figure 9. — Ena/VASP activity affects actomyosin contractility. (A) Western blots with antibodies to total or phosphorylated MLC show that inactivation of Ena/VASP in HUVECs reduces the level of MLC expression, whereas cells overexpressing Ena/VASP have higher levels of MLC expression. (B) Quantitation of total and phospho MLC (*, P < 0.05; n = 5). Error bars represent SD. (C) HUVEC cells with inactivated Ena/VASP exert less force, as measured by contraction of collagen matrices, whereas overexpression of VASP increases force generation compared with GFP control (*, P < 0.05; n = 10). Contraction of HUVECs expressing AP4-Mito was statistically indistinguishable from GFP control (not depicted).