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. 2007 Nov 19;179(4):593–600. doi: 10.1083/jcb.200708054

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — DNA content does not directly determine nuclear size. Quantitation of nuclear and cell size in over-replicating cells. pnmt1-driven switch-off of the cyclin Cdc13 induces over-replication in a subset of cells (marked in red). Cells arrested with 2C DNA content are marked in blue. (A) For quantitative DAPI staining (right panel), cells were formaldehyde fixed 10 h after cdc13 switch-off. Left panel: overlay of DIC and Cut11-GFP. Bar, 10 μm. (B) FACS profile for DNA content shows the kinetics of cdc13 switch-off dependent over-replication (log scale FL2-H). Cell and nuclear size are represented in a scatter plot, N/C ratio in a Box-and-Whisker plot.