Figure 3.

(a) ¹H NMR spectra of the amide regions of N5-C77 (Upper) and N5-C64 (Lower). (b) A portion of the nuclear Overhauser effect spectroscopy (NOESY) spectrum for N5-C77 showing the d_NN connectivities for residues 49–59. (c) Summary of sequential and medium range connectivities for residues 49–59. The gap in the d_NN (i, i+1) connectivity and the dashed lines in the medium-range connectivities also indicate overlap. (d) A schematic showing the bipartite recognition helix of Skn in DNA binding. The tertiary structure of the folded domain has not been sufficiently defined to include in the model.