Table 3.

Effect of RIN and probe sensitivity to RNA degradation on assay sensitivity. The percent sensitivity for a false positive rate of 10% [and 95% Confidence Interval] is reported for liver selective probe sets that significantly decrease in response to RNA degradation (LS_DEC), all liver selective probe sets (LS_ALL), and liver selective probe sets that are invariant to RNA degradation (LS_INV).

Fold change	RIN group	LS_DEC	LS_ALL	LS_INV
1.5	9.5	97.2 [85.8, 99.7]	92.9 [88.2, 96.1]	100 [94.0, 100]
	8	92.4 [78.7, 98.1]	92.0 [87.5, 95.2]	100 [93.6, 100]
	7	72.7 [55.2, 85.9]	88.7 [82.0, 93.4]	100 [90.3, 100]
	6	68.4 [51, 82.5]	88.3 [82.9, 92.4]	100 [84.5, 100]
2	9.5	99.2 [90.7, 100]	96.3 [93.3, 98.1]	100a
	8	94.3 [82.6, 98.7]	94.7 [91.6, 96.8]	99.9 [80.3, 100]
	7	84.2 [68.7, 93.6]	93.8 [89.4, 96.7]	100 [39.5, 100]
	6	83.6 [68.3, 93.1]	93.3 [89.3, 96.0]	100 [79.7, 100]
4	9.5	99.0 [89.3, 100]	96.9 [94.5, 98.4]	100a
	8	96.4 [85.8, 99.4]	95.7 [93.1, 97.5]	100a
	7	87.8 [74.1, 95.4]	95.3b	100a
	6	87.6 [74.2, 95.2]	94.6 [91.6, 96.7]	100a

^aNo CI (for perfect discrimination, data cannot be fitted to a ROC curve)

^bValue interpolated from empirical data using Weibull cumulative discrimination function