Fig. 3.

Inhibition of ERK pathway decreases the proliferation of neural progenitor cells. Neural progenitor cells were incubated under normoxic conditions in the presence and absence of U0125 (10uM) (ERK inhibitor) for 4 h. After the experimental period, cells were subsequently cultured in neurobasal medium containing B27 and FGF2 for 5 days. At the end of experimental period the cells were photographed and cell proliferation assay was performed as described in methods. * P < 0.05 as compared to normoxic cells.