Table 5.
Ganglioside Content and Distribution in Caudate of Huntington Disease Subjects
| Control | HD | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | Average | 1 | 2 | 3 | Average | ||||||
| Age | 49 | 55 | 22 | 42 | 46 | 53 | 54 | 51 | |||||
| Sex | M | M | M | - | M | F | M | - | |||||
|
Ganglioside content (μg sialic acid / 100 mg dry weight)a |
Difference % |
||||||||||||
| Total | 205 | 393 | 276 | 291 ± 55 | 172 | 260 | 93 | 175 ± 48 | -40 | ||||
| GM1 | 37.4 | 58.6 | 82.0 | 59.3 ± 12.9 | 36.6 | 53.5 | 18.8 | 36.3 ± 10.0 | -39 | ||||
| GD3 | 8.8 | 3.5 | 3.8 | 5.4 ± 1.7 | 9.9 | 16.9 | 15.5 | 14.1 ± 2.2 * | 162 | ||||
| GD1a | 45.9 | 115.2 | 88.1 | 83.1 ± 20.2 | 42.9 | 52.5 | 16.2 | 37.2 ± 10.9 | -55 | ||||
| GD2 | 7.1 | 3.8 | 2.0 | 4.3 ± 1.5 | 2.4 | 4.1 | 1.6 | 2.7 ± 0.7 | -37 | ||||
| GD1b | 46.3 | 85.4 | 43.7 | 58.5 ± 13.5 | 36.4 | 58.4 | 14.7 | 36.5 ± 12.6 | -38 | ||||
| GT1b | 52.5 | 112.2 | 51.5 | 72.0 ± 20.1 | 39.7 | 64.4 | 22.7 | 42.2 ± 12.1 | -41 | ||||
| GQ1b | 7.4 | 13.8 | 5.2 | 8.8 ± 2.6 | 4.5 | 10.6 | 3.4 | 6.2 ± 2.2 | -30 | ||||
a
Determined from densitometric scanning of HPTLC as shown in Figure 6.
*
Indicates that the value is significantly different from that of the control caudate at p < 0.05 as determined by the two-tailed Student’s t-test.