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Dose response for LPS at various doses and various time points. We found that LPS causes a significant increase in IL-6 in the supernatant. We found that 100 μg/mL resulted in the greatest IL-6 increase 24 h after LPS administration. Similarly, the insulin dose response showed that insulin at 10 IU/mL demonstrated significant effects when hepatocytes were exposed to 100 μg/mL LPS. *Significant difference between controls and insulin 10 U/mL after LPS administration, P < 0.05.
