Figure 7. Thrombus formation but not fibrin generation is defective in BSDL-null mice in comparison with wild-type mice.

(A) Bleeding time in seconds determined in BSDL-null (10 mice) and wild-type (10 mice) mice. Bars indicate median values; **P < 0.001. (B) Median fibrin integrated fluorescence intensity in thrombi after laser-induced injury in wild-type (30 thrombi; 3 mice) and BSDL-null mice (28 thrombi; 3 mice). An Alexa Fluor 488–labeled monoclonal antibody specific for fibrin (0.4 μg/g mouse) was infused prior to laser injury.