Figure 2. Prenatal Arsenic Exposure Results in Robust Genome-Wide Changes.
(A) Heat map of the 447 differentially expressed genes identified between two newborn populations, those born to unexposed or arsenic exposed mothers. The cut point of exposure is indicated with a red dotted line. Unlike Figure 1, the differentially expressed transcripts did not have to display a significant trend with increasing arsenic exposure. Expression values are mean centered with high relative expression indicated in red and low relative expression indicated in blue.
(B) The 285 arsenic-modulated gene products existing in the Ingenuity database were analyzed for significant enrichment of molecular interactions. A significant (p < 10−55) interactome containing 105 arsenic-modulated gene products was identified. Proteins in red represent arsenic-induced transcripts, proteins in green represent arsenic-repressed transcripts.