Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Nov 23;3(11):e235. doi: 10.1371/journal.pcbi.0030235

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2007 Kaplan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A–C) Simulation results show the long allele distribution at onset for heterozygote patients (A) with onset at 60 y and homozygote patients (B) with onset at 56 y, both with 40 inherited repeats. The homozygote patients show more narrow distribution, which is closer to the pathological threshold, which leads to a faster disease progression.

(C) The difference in age of onset is rather small (homozygote ∼6% earlier) and therefore is undetectable considering other variability factors; however, the difference in progression is significant (homozygote ∼30% faster).