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Arrhythmic activity resulting from extrasystolic stimulation. Epicardial monophasic action potential (MAP) recordings illustrating the result of the application of extrasystolic stimuli to WT (a), Scn5a+/Δ (b) and Scn5a+/− (c) hearts treated with control solution (A) and with solutions containing 1 μM flecainide (B), 1 μM quinidine (C) and 10 μM quinidine (D). Traces show arrhythmic activity where this was observed in ≥50% of cases
