Table 1.
Fit parameters for epicardial restitution curves
| Condition | y0 (ms) | A (ms) | τ (ms) | χ2 |
|---|---|---|---|---|
| WT (6 hearts) | 1.6 ± 4.4 | 56.2 ± 2.4 | 58.4 ± 9.8 | 1.4 |
| WT + flecainide (5 hearts) | −16.3 ± 9.4 | 104.7 ± 7.1 | 82.8 ± 28.0 | 5.9 |
| WT + 1 μM quinidine (6 hearts) | −38.3 ± 17.4 | 92.4 ± 14.7 | 45.1 ± 9.4 | 2.5 |
| WT + 10 μM quinidine (6 hearts) | −863.0 ± 1,387.1 | 981.6 ± 1,369.1 | 27.1 ± 15.9 | 113.3 |
| Scn5a+/Δ (5 hearts) | −19.6 ± 7.2 | 90.0 ± 4.4 | 53.1 ± 10.7 | 14.0 |
| Scn5a+/Δ + flecainide (5 hearts) | −16.1 ± 6.5 | 82.2 ± 12.3 | 95.3 ± 42.1 | 3.5 |
| Scn5a+/Δ + 1 μM quinidine (5 hearts) | −677.1 ± 306.1 | 748.0 ± 304.7 | 15.2 ± 2.2 | 10.0 |
| Scn5a+/− (6 hearts) | −674.8 ± 329.9 | 729.4 ± 329.1 | 14.2 ± 2.1 | 8.4 |
| Scn5a+/− + flecainide (6 hearts) | −56,359.8 ± 2,559.7 | 52,677.3 ± 2.2 | 7.8 ± 2.5 | 14.8 |
| Scn5a+/− + 1 μM quinidine (5 hearts) | −118.3 ± 57.4 | 202.5 ± 49.4 | 36.4 ± 10.5 | 16.7 |
| Scn5a+/− + 10 μM quinidine (7 hearts) | −1.7 ± 44.7 | 131.9 ± 62.3 | 158.4 ± 262.2 | 10.8 |
Results of least-squares fits to the function 
under the conditions indicated