Table 3.
Fit parameters for endocardial restitution curves separating successive odd- and even-numbered action potentials
| Condition | Odd | Even | ||||||
|---|---|---|---|---|---|---|---|---|
| y0 (ms) | A (ms) | τ (ms) | χ2 | y0 (ms) | A (ms) | τ (ms) | χ2 | |
| WT (6 hearts) | 13.4 ± 7.6 | 40.5 ± 12.9 | 50.3 ± 21.4 | 6.3 | 8.1 ± 11.2 | 58.3 ± 25.4 | 48.2 ± 32.3 | 4.6 |
| WT + flecainide (5 hearts) | −14.7 ± 8.9 | 105.2 ± 9.0 | 88.0 ± 31.3 | 5.8 | −44.6 ± 18.5 | 117.4 ± 14.2 | 49.0 ± 9.9 | 1.5 |
| WT + 1 μM quinidine (6 hearts) | −20.6 ± 9.9 | 75.8 ± 6.2 | 56.4 ± 13.2 | 3.8 | −34.2 ± 11.7 | 89.2 ± 9.3 | 45.9 ± 7.8 | 3.3 |
| WT + 10 μM quinidine (6 hearts) | −1,391.7 ± 3,195.9 | 1,496.0 ± 3,182.0 | 21.1 ± 14.3 | 117.9 | −393.1 ± 5.3.0 | 532.8 ± 481.7 | 41.1 ± 27.6 | 115.7 |
| Scn5a+/Δ (5 hearts) | −23.9 ± 8.3 | 92.0 ± 5.3 | 47.8 ± 9.0 | 12.4 | −24.4 ± 8.6 | 92.6 ± 5.6 | 47.6 ± 8.9 | 11.8 |
| Scn5a+/Δ + flecainide (5 hearts) | 14.6 ± 6.3 | 77.1 ± 8.4 | 84.1 ± 32.2 | 3.4 | −33.2 ± 46.4 | 110.1 ± 41.9 | 36.4 ± 13.1 | 2.0 |
| Scn5a+/Δ + 1 μM quinidine (5 hearts) | −250.2 ± 12.8 | 483.0 ± 24.5 | 18.8 ± 7.8 | 12.4 | −254.7 ± 321.2 | 328.1 ± 318.3 | 20.0 ± 7.7 | 5.3 |
| Scn5a+/− (6 hearts) | −850.4 ± 282.7 | 904.2 ± 282.1 | 13.5 ± 1.3 | 4.3 | −913.3 ± 283.3 | 968.6 ± 282.7 | 13.7 ± 1.2 | 3.7 |
| Scn5a+/− + flecainide (6 hearts) | −1,473.8 ± 3,144.5 | 1,534.3 ± 2,141.2 | 14.7 ± 7.6 | 34.3 | −2,108.8 ± 4,489.9 | 2,171.3 ± 4,486.8 | 14.0 ± 6.7 | 35.0 |
| Scn5a+/− + 1 μM quinidine (5 hearts) | −46.8 ± 51.2 | 146.8 ± 21.3 | 59.5 ± 43.5 | 9.4 | −46.7 ± 50.6 | 149.2 ± 20.2 | 61.0 ± 44.2 | 9.3 |
| Scn5a+/− + 10 μM quinidine (7 hearts) | 7.3 ± 34.2 | 167.7 ± 264.8 | 272.8 ± 78.3 | 10.8 | 2.8 ± 44.6 | 143.1 ± 121.3 | 192.2 ± 405.8 | 12.0 |
Results of least-squares fits to the function 
under the conditions indicated