Table 4.
Fit parameters for endocardial restitution curves separating successive odd- and even-numbered action potentials
| Condition | Odd | Even | ||||||
|---|---|---|---|---|---|---|---|---|
| y0 (ms) | A (ms) | τ (ms) | χ2 | y0 (ms) | A (ms) | τ (ms) | χ2 | |
| WT (6 hearts) | −17.4 ± 5.3 | 73.8 ± 2.8 | 67.3 ± 13.5 | 4.7 | −38.9 ± 15.4 | 91.6 ± 13.0 | 46.5 ± 8.5 | 1.8 |
| WT + flecainide (5 hearts) | −49.2 ± 26.2 | 113.8 ± 23.0 | 35.7 ± 8.2 | 7.6 | −367.3 ± 171.3 | 426.9 ± 170.6 | 17.7 ± 2.4 | 1.3 |
| WT + 1 μM quinidine (6 hearts) | −393.2 ± 368.6 | 437.7 ± 368.6 | 14.9 ± 4.3 | 18.1 | −1,337.3 ± 1,206.4 | 1,384.5 ± 1,205.7 | 11.5 ± 2.5 | 14.7 |
| WT + 10 μM quinidine (6 hearts) | −17.7 + −39.0 | 53.2 ± 35.0 | 42.6 ± 28.9 | 11.2 | −28.0 ± 62.7 | 66.6 ± 58.2 | 39.6 ± 29.7 | 17.3 |
| Scn5a+/Δ (5 hearts) | −149.6 ± 131.4 | 221.0 ± 128.6 | 26.4 ± 7.6 | 0.9 | −42.3 ± 10.5 | 115.3 ± 8.2 | 40.8 ± 5.0 | 2.6 |
| Scn5a+/Δ + flecainide (5 hearts) | −1,133.8 ± 784.2 | 1,201.4 ± 783.1 | 15.2 ± 2.6 | 2.0 | −2,164.0 ± 1,195.7 | 2,233.3 ± 1,195.0 | 13.6 ± 1.6 | 1.4 |
| Scn5a+/Δ + 1 μM quinidine (5 hearts) | −2,720.4 ± 3,917.8 | 2,779.7 ± 3,917.2 | 10.4 ± 2.8 | 3.4 | −3,527.2 ± 4,674.78 | 3,603.0 ± 4,674.1 | 11.1 ± 2.7 | 3.9 |
| Scn5a+/− (6 hearts) | −134.6 ± 28.9 | 195.3 ± 28.0 | 22.8 ± 2.1 | 3.3 | −149.1 ± 33.5 | 212.0 ± 32.6 | 22.9 ± 2.2 | 3.6 |
| Scn5a+/− + flecainide (6 hearts) | −13.8 ± 29.2 | 66.2 ± 27.1 | 32.5 ± 11.1 | 1.8 | −55.4 ± 55.5 | 108.6 ± 54.6 | 23.6 ± 5.9 | 1.2 |
| Scn5a+/− + 1 μM quinidine (5 hearts) | −1,979.9 ± 1,709.0 | 2,051.5 ± 1,704.6 | 15.9 ± 2.8 | 13.4 | −108.4 ± 15,101.8 | 10,911.4 ± 15,098.3 | 11.8 ± 3.0 | 14.8 |
| Scn5a+/− + 10 μM quinidine (7 hearts) | −332.1 ± 447.2 | 431.4 ± 439.8 | 25.2 ± 12.7 | 116.0 | −160.0 ± 289.5 | 262.2 ± 281.9 | 20.1 ± 18.1 | 48.1 |
Results of least-squares fits to the function 
under the conditions indicated