Figure 2 Schematic representation of appetite control—actions of gut hormones and long term adiposity signals on neuronal populations in the arcuate nucleus and the integrated response of anorexigenic and orexigenic populations of neurones in the hypothalamus. ARC, arcuate nucleus; PVN, paraventricular nucleus; LHA, lateral hypothalamic area; CRF, corticotroph releasing factor; TRH, thyrotropin releasing factor (form part of integration with energy expenditure); NPY, neuropeptide Y; AgRP, agouti related peptide; POMC, proopiomelanocortin; CART, cocaine and amphetamine regulated transcript; MCH, melanin concentrating hormone; CCK, cholecystokinin; GLP‐1, glucagon‐like peptide 1; PYY, peptide YY; Oxm, oxyntomodulin; PP, pancreatic polypeptide.