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. 2005 Dec 2;91(2):131–138. doi: 10.1136/adc.2005.086918

Table 2 Summary of results from studies on sunburn during childhood and adolescence and melanoma skin cancer.

First author (reference), year, location Study design Assessment of sun exposure Critical age periods investigated RR/OR (95% CI) Adjusted RR/OR (95% CI) Comments
No. cases/controls
Sunburn
Lew,68 1983, USA Case‐control 111/107 Painful sunburns (childhood) Childhood N/A 2.8 (1.3–6.3) (childhood) No adjustment for confounders; painful sunburn during childhood assessed in good tanners
Blistering sunburns (adolescence) (yes v no) Adolescence 2.05 (1.18–3.56) (adolescence)
Elwood,74 1984, Canada Case‐control 595/595 Episodes of severe sunburn (severe/frequent v rare/mild) Childhood 1.9 (N/A) 1.3 (0.9–1.8) Adjusted for hair, skin/eye colour, freckles, sun reaction, and ethnicity
Holman,73 1986, Australia Case‐control 507/507 ⩾5 painful sunburns v none Childhood (age <10 y) N/A 1.11 (0.51–2.41) (childhood) Limited to superficial spreading melanoma; adjusted for acute, chronic skin reaction, hair colour, country of origin, and age at arrival
Adolescence (age 15–24 y) 0.98 (0.53–1.82) (adolescence)
Cristofolini,86 1987, Italy Case‐control 103/205 Severe sunburn (yes v no) Adolescence or early adult life N/A 0.70 (0.41–1.19) Adjustment for age and sex only
Østerlind,56 1988, Denmark Case‐control 474/926 ⩾5 Painful (severe) sunburns v never Childhood (age <15 y) 3.7 (2.3–6.1) (childhood) 2.7 (1.6–4.8) (childhood) Adjusted for sex, number of nevi, freckles, and hair colour; dose response apparent
Adolescence (age 15–24 y) 2.4 (1.6–3.6) (adolescence) 1.9 (1.2–3.1) 1.2 (0.6–2.7)* (adolescence)
Weinstock,41 1989, USA Nested case‐control 130/300 ⩾5 Blistering sunburns v 0 Adolescence (age 15–20 y) 1.9 (1.1–3.4) N/A No adjustment for confounders
Elwood,75 1990, UK Case‐control 195/195 Severe sunburn (ever v never) Childhood (age 8–12 y) N/A 2.4 (0.8–7.3) Adjusted for nevi, freckling, social class, hair colour, and tendency to burn
Zanetti,70 1992, Italy Case‐control 260/416 Sunburn (often) v never Childhood 12.0 (4.6–31.0) (sunburn often) 3.8 (2.3–6.4) (ever sunburn childhood) Adjusted for sex, age, and type of skin reaction; dose response effect
Severe sunburn v never 6.5 (3.4–12.3) (severe sunburn)
Nelemans,60 1993, Netherlands Case‐control 141/183 History of sunburn (yes v no) Adolescence (age 15–25 y) N/A 3.90 (1.82–8.33) (indoor worker) Adjusted for age, sex, education, tendency to burn, hair colour, and, freckling. Effect modification apparent: increased risk in sun sensitive individuals
1.90 (0.89–4.06) (outdoor worker)
Autier,76 1994, Belgium, France, Germany Case‐control 420/447 ⩾5 Painful sunburns Childhood (age 5–14 y) 1.75 (1.09–3.01) (childhood) 1.49(0.97–2.32) (childhood) Adjusted for hair/eye colour, ability to tan, nevi count, and density of freckles
Adolescence (> age 14 y) 1.86 (1.19–2.46) (adolescence)
Garbe,84 1994, Germany Case‐control 513/498 No. of sunburns Childhood and adolescence (age <20 y) N/A N/A Number of sunburns higher in cases
Westerdahl,77 1994, Sweden Case‐control 400/640 >5 Sunburns v never Childhood (<age 15 y) 1.0 (0.5–2.1) (childhood) 1.6 (1.0–2.6) (childhood) Adjusted for nevi and hair colour
Adolescence (age 15–19 y) 0.9 (0.4–2.1) (adolescence) 1.6 (1.0–2.5) (adolescence)
Holly,78 1995, USA Case‐control 452/930 Severe/frequent v rare/mild/no sunburn; ⩾7 painful sunburns v none Childhood (⩽age 12 y); elementary and high school 3.3 (2.3–4.7) (childhood) 1.9 (1.2–3.0) (childhood) Adjusted for sunscreen use, skin reaction to sun, hair colour, nevi, complexion, ethnicity, history of skin cancer, and age; dose response apparent; effect modification by ability to tan
2.0 (1.4–2.9) (elementary school)
2.4 (1.6–3.5) (high school)
Ródenas,79 1996, Spain Case‐control 105/138 Painful sunburn (often v never); blistering sunburn (yes v no); sunbaths (211 v 0) Childhood (< age 15 y) N/A 2.4 (1.1–5.52) (painful sunburn) Adjusted for age, skin colour and type; dose response apparent.
3.6 (1.5–8.4) (blistering sunburn)
5.5 (2.3–13.3) (sunbaths)
Pfahlberg,83 2001, Europe Case‐control 603/627 ⩾6 sunburns v none Childhood (⩽age 15 y) N/A 2.0 (1.2–3.5) Adjusted for location, ethnic origin, age and sex
Kaskel,72 2001, Germany Case‐control 271/271 Sunburn ever v never Childhood (⩽12 y) 5.7 (3.2–10.1) 1.9 (0.9–4.2) Adjusted for age, gender, and residence
Siskind,80 2002, Australia Case‐control 1263/3111 Hours in summer sun on weekdays, weekends and holidays Childhood (age 5–12 y) N/A 1.2 (1.1–1.3) Adjusted for skin colour, hair colour, propensity to burn, nevus density, and age
Kennedy,85 2003, Netherlands Case‐control 80/386 Painful sunburn Childhood/adolescence (age 0–19 y) N/A 1.4 (0.9–2.1) Adjustment for age, sex, and skin type
Soloman,81 2004, USA Case‐control 386/727 No. of sunburns (3+ v none) Female childhood (age 2–10 y) N/A 3.4 (2.2–5.4) Adjustment for age, sex, income, tendency to burn, and sunburns during age 2–10
Female adolescence (age 11–20 y) 3.3 (2.0–5.3)
Male childhood (age 2–10 y) 1.8 (1.2–2.8)
Male adolescence (age 11–20 y) 2.3 (1.4–3.5)
Bataille,82 2004, UK Case‐control 413/416 Severity of sunburns (ever v never) Childhood (< age 15 y) 1.6 (1.1–2.3) 1.3 (0.9–2.0) Adjusted for age, gender, and skin type