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. Author manuscript; available in PMC: 2007 Nov 21.
Published in final edited form as: Cancer Res. 2007 Mar 1;67(5):2015–2021. doi: 10.1158/0008-5472.CAN-06-3617

Figure 6.

Figure 6

A, effects of EP2 and EP4 agonist on the UVB-induced apoptosis in COX-2−/− mice. EP agonists (25 μmol) were applied to COX-2−/− mice 30 min before UVB exposure (5.0 kJ/m2), and the mice were sacrificed 24 h later. Columns, mean of the percent apoptotic cells (TUNEL positive) per 100 basal cells; bars, SD (n = 5 mice per group). *, P < 0.01. B, a proposed pathway for p53 and EP2/EP4 signaling in UVB-induced epidermal apoptosis.