Figure 5. Cell Death in Cells Isolated from FCAS Patients and in Cells Expressing Wild-Type CIAS1.
(A) Cell viability is decreased in PBMCs from FCAS patients in response to LPS. XTT reduction was used to assay cell viability and was measured 72 hr after stimulation. *p < 0.05, **p < 0.01 when compared to controls.
(B) Cell viability is diminished in THP-1 cells expressing wild-type CIAS1 at higher multiplicities of infection. XTT reduction was measured 48 hr after adenoviral infection.
All values are the mean of three independent experiments. Error bars indicate standard deviation of the mean.