Table 2.

Comparison of pre-existing medical conditions among ECC cases, ICC cases and controls¹

	ECC Cases (n=549)			ICC Cases (n=535)			Controls (n=102,782)
	n	%	p value	n	%	p value	n	%
Biliary tract conditions and operations
Cholecochal cysts	27	4.9	<0.001	21	3.9	<0.001	108	0.1
Cholangitis	50	9.1	<0.001	67	12.5	<0.001	201	0.2
Biliary cirrhosis	<5	<0.9	0.003	5	0.9	<0.001	53	0.1
Cholelithiasis	202	36.8	<0.001	172	32.1	<0.001	4,273	4.2
Choledocholithiasis	87	15.8	<0.001	59	11	<0.001	543	0.5
Cholecystitis	42	7.7	<0.001	29	5.4	<0.001	973	0.9
Cholecystectomy	87	15.8	<0.001	41	7.7	<0.001	1,649	1.6
Liver flukes	-	-	-	-	-	-	-	-
Chronic liver diseases
Alcoholic liver disease	8	1.5	<0.001	5	0.9	0.008	310	0.3
Nonspecified cirrhosis	10	1.8	<0.001	17	3.2	<0.001	359	0.3
Hemochromatosis	<5	<0.9	0.25	<5	<0.9	0.05	282	0.3
Chronic non-alcoholic liver disease	<5	<0.9	0.08	5	0.9	0.03	353	0.3
HCV infection	<5	<0.9	0.36	<5	<0.9	0.03	142	0.1
Endocrine Disorders
Diabetes mellitus type II	165	30.1	<0.001	177	33.1	<0.001	22,764	22.1
Thyrotoxicosis	30	5.5	0.04	27	5	0.12	3,864	3.8
Digestive disorders
Inflammatory Bowel Disease	10	1.8	0.03	18	3.4	<0.001	936	0.9
Crohn's Disease	6	1.1	0.02	5	0.9	0.06	419	0.4
Ulcerative Colitis	5	0.9	0.11	13	2.4	<0.001	595	0.6
Duodenal ulcer	20	3.6	0.001	34	6.4	<0.001	1,836	1.8
Chronic pancreatitis	13	2.4	<0.001	8	1.5	<0.001	272	0.3
Miscellaneous conditions
Smoking	12	2.2	0.03	12	2.2	0.02	1,212	1.2
Obesity	16	2.9	0.79	23	4.3	0.12	3,201	3.1

¹Cells sizes less than five are suppressed according to the SEER-Medicare data use agreement

²Fisher's Exact test used to compute p value where n<5