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Model for the possible role of structural changes in putative protein-protein interactions. Cartoon representation of how human ferrochelatase (Fc) might interact with protoporphyrinogen oxidase (PPO) during binding of protoporphyrin IX. Following iron insertion the π helix is unwound and a new binding surface is presented for the release of protoheme to a currently unidentified heme carrier protein (HCP). The inner mitochondrial membrane is shown as solid lines.
