Table 2.
Quantitative trait loci for atherosclerosis in inbred mouse crosses
| Chr | Crossa | markerb | cM (CI)c | Mb (CI)d | LODe | locus | Reference |
|---|---|---|---|---|---|---|---|
| 1 | B × H and C × B RI lines | D1Mit159 | 82 | 162 (151–170) | … | Ath1 | (Paigen et al., 1987c; Phelan et al., 2002) |
| (B6 × A) F2 | 1–169 Mb | 100 | 178 (169–195) | 3.4 | Ishimori et al, unpublished | ||
| (B6.129-Apoe−/− × FVB.129-Apoe−/−) F2 | D1Mit359 | 100 | 178(169–195) | 3.3 | Ath9 | (Dansky et al., 2002) | |
| 2 | (PERA × B6.129-Ldlr−/−) × B6.129-Ldlr−/− | D2Mit405 | 69 | 148 (117–152) | 2.8 | Athla1 | (Bretschger Seidelmann et al., 2005) |
| (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13476938 | 107 | 179 (174–179) | 3.3 | Ath28 | (Smith et al., 2006) | |
| 3 | (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13477166 | 33 | 67 (53–89) | 2.7 | Ath23 | (Smith et al., 2006) |
| (B6.129-Ldlr−/− × FVB.129-Ldlr −/−) F2 | D3Mit57 | 55 | 119 (90–131) | 4.1 | Ascla4 | (Teupser et al., 2006) | |
| (FVB.129-Ldlr −/− × B6.129-Ldlr −/−) F2 | D3Mit45 | 79 | 148 (141–160) | 3.3 | Ascla3 | (Teupser et al., 2006) | |
| 4 | (B6.129-Apoe−/− × C3H.129-Apoe−/−) F2 | D4Mit111 | 22 (3–50) | 52 (10–102) | 3.0 | (Wang et al., 2003b) | |
| (SM × NZB) F2 | D4Mit44 | 29 (18–51) | 59 (46–104) | 3.6 | Ath8 | (Korstanje et al., 2004) | |
| (A × B6.129-Apoe−/−) F2 | 4–135 Mb | 76 | 143 (136–154) | 4.6 | Ishimori et al, unpublished | ||
| (MOLF × B6-Ldlr−/−) × B6-Ldlr−/− | D4Mit127 | 78 (66–81) | 149 (136–151) | 6.2 | Athsq1 | (Welch et al., 2001) | |
| 5 | (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13478585 | 84 | 147 (130–139) | 3.4 | Ath24 | (Smith et al., 2006) |
| 6 | (CAST × B6) F2 | D6Mit256 | 61 (46–71) | 127 (105–144) | 6.7 | Artles | (Mehrabian et al., 2001) |
| (MOLF × B6-Ldlr−/−) × B6-Ldlr−/− | D6Mit110 | 64 (52–70) | 136 (115–143) | 6.7 | Athsq2 | (Welch et al., 2001) | |
| 7 | (B6 × DBA/2) F2 | D7Mit193 | 25 | 51 (33–68) | 3.7 | Aorls2 | (Colinayo et al., 2003) |
| A × B and B × A RI lines | Tyr | 44 (20–50) | 87 (41–100) | … | Ath3 | (Stewart-Phillips et al., 1989) | |
| 8 | (B6 × A) F2 | 8–54 Mb | 22 | 36 (31–67) | 2.8 | Ishimori et al, unpublished | |
| (B6 × DBA/2) F2 | D8Mit41 | 29 | 49 (39–88) | 3.4 | (Colinayo et al., 2003) | ||
| (A × B6.129-Apoe−/−) F2 | 8–109 Mb | 60 | 120 (106–129) | 2.0 | Ishimori et al, unpublished | ||
| 9 | (B6 × A) F2 | 9–48 Mb | 25 | 43 (34–63) | 4.1 | Ishimori et al, unpublished | |
| SWR (SWR × SJL) | D9Mit330 | 26 | 45 (36–66) | Svenson et al, unpublished | |||
| (A × B6.129-Apoe−/−) F2 | 9–64 Mb | 42 | 74 (60–98) | 3.7 | Ishimori et al, unpublished | ||
| (B6.129-Apoe−/− × C3H.129-Apoe−/−) F2 | D9Mit156 | 42 | 74 (60–98) | 4.1 | Ath22 | (Su et al., 2006) | |
| 10 | (B6 × 129) F2 | D10Mit213 | 10 (5–40) | 19 (12–74) | … | Ath20g | (Ishimori et al., 2004) |
| (B6.129-Apoe−/− × FVB.129-Apoe−/−) F2 | D10Mit213 | 11 (0–29) | 20 (0–51) | 5.1 | Ath11 | (Dansky et al., 2002) | |
| (A × B6.129-Apoe−/−) F2 | 10–27 Mb | 12 | 22 (7–29) | 2.8 | Ishimori et al, unpublished | ||
| (B6.129-Ldlr −/− × FVB.129-Ldlr −/−) RpF2 | D10Mit16 | 16 | 21 (14–43) | 13.1 | Ascla1 | (Teupser et al., 2006) | |
| (B6 × A) F2 | 10–27 Mb | 20 | 26 (18–55) | 3.9 | Ishimori et al, unpublished | ||
| (B6 × DBA/2) F2 | D10Mit42 | 30 (14–45) | 55 (20–88) | 4.5 | Aorls1 | (Colinayo et al., 2003) | |
| (B6 × 129) F2 | D10Mit31 | 34 (30–36) | 67 (55–68) | 6.6 | Ath17 | (Ishimori et al., 2004) | |
| 11 | (B6.129-Apoe −/− × C3H.129-Apoe −/−) F2 | D11Mit236 | 20 | 44 (20–56) | 2.4 | (Su et al., 2006) | |
| (B6 × 129) F2 | D11Mit333 | 60 (55–70) | 99 (94–113) | … | Ath19g | (Ishimori et al., 2004) | |
| 12 | (B6-db/db × BKS) F2 | D12Mit49 | 3 (2–4) | 13 (9–15) | 2.5 | Ath6 | (Mu et al., 1999) |
| (B6.129-Ldlr−/− × FVB.129-Ldlr−/−) RpF2 | D12Mit82 | 3 | 13 (0–39) | 3.9 | Ascla5 | (Teupser et al., 2006) | |
| (B6 × 129) F2 | D12Mit243 | 16 (13–17) | 36 (32–38) | 3.7 | Ath18 | (Ishimori et al., 2004) | |
| (B6.129-Ldlr−/− × FVB.129-Ldlr−/−) RpF2 | D12Mit189 | 24 (0–34) | 55 (0–79) | 4.8 | Ascla6 | (Teupser et al., 2006) | |
| SWR × (SWR × SJL), SWR × SJL RI | D12Mit158 | 38 (35–40) | 85 (81–86) | Ath7 | Svenson et al, unpublished | ||
| (B6 × 129) F2 | D12Mit7 | 50 (10–70) | 103 (27–119) | … | Ath21g | (Ishimori et al., 2004) | |
| 13 | (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13481782 | 26 | 43 (33–67) | 2.8 | Ath25 | (Smith et al., 2006) |
| 14 | (B6.129-Apoe−/− × FVB.129-Apoe−/−) F2 | D14Mit60 | 15 (10–40) | 45 (28–70) | 2.5 | Ath13 | (Dansky et al., 2002) |
| (A × B6.129-Apoe−/−) F2 | 14–52 Mb | 22 | 55 (31–69) | 2.6 | Ishimori et al, unpublished | ||
| 15 | (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13482467 | 14 | 20 (10–29) | 3.3 | Ath22 | (Smith et al., 2006) |
| 16 | (B6.129-Apoe−/− × FVB.129-Apoe−/−) F2 | D16Mit103 | 22 | 29 (13–45) | 2.5 | (Dansky et al., 2002) | |
| 17 | (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13482966 | 20 | 36 (33–54) | 4.3 | Ath26 | (Smith et al., 2006) |
| 18 | (B6.129-Ldlr−/− × FVB.129-Ldlr−/−) F2 | D18Mit23 | 21 | 44 (21–57) | 3.1 | (Teupser and Breslow, 2004) | |
| (A × B6.129-Apoe−/−) F2 | 18–52 Mb | 22 | 46 (23–59) | 2.5 | Ishimori et al, unpublished | ||
| (AKR.129-Apoe−/− × DBA/2.129-Apoe−/−) RpF2 | rs13483316 | 22 | 41 (39–57) | 3.6 | Ath27 | (Smith et al., 2006) | |
| 19 | (B6.129-Apoe−/− × FVB.129-Apoe−/−) F2 | D19Mit120 | 41 (6–54) | 42 (12–58) | 3.8 | Ath16 | (Dansky et al., 2002) |
| ? | A × B RI, B × A RI | … | Ath2 | (Paigen, 1995) |
a
RI, recombinant inbred strains; F2, intercross; RpF2, reciprocal F2—both strains were used as female and male parental strains, and the F2s were combined for analysis.
b
Peak marker. The non-MIT markers are all SNP markers with their positions (for example, 1–169 Mb means a SNP on Chr 1, at 169 Mb).
c
cM, peak centimorgan. Genetic distances were retrieved from MGI at http://www.informatics.jax.org. CI: 95% confidence interval.
d
Mb, megabase, derived from the physical positions (Ensembl NCBI m36, Gene build April 2006) of the markers at the corresponding cM position. In the absence of information on CI in cM, peak ± 10 cM is used instead.
e
LOD, logarithm of the odds ratio