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. Author manuscript; available in PMC: 2008 Oct 1.
Published in final edited form as: Neurobiol Learn Mem. 2007 Aug 21;88(3):277–294. doi: 10.1016/j.nlm.2007.07.007

Fig. 8. Synaptophysin immunoreactivity in CA1 and CA3 hippocampal areas for APPsw+PS1 mice raised in various housing environments.

Fig. 8

Transgenic mice raised in “complete” EE (enhanced cognitive activity) had increased synaptophysin immunoreactivity in hippocampal CA1 (A) and CA3 regions (B) compared to transgenic mice raised in all other housing environments. *p<0.05, **p<0.005 vs. all other groups. (C) Photomicrographic examples of synaptophysin immunoreactivity in hippocampal CA1 (left panels) and CA3 (right panels) for transgenic mice raised in IMP, SH, PA, or EE housing. Note the enhanced synaptophysin immunoreactivity seen exclusively for Tg mice raised in complete EE housing (i.e., enhanced cognitive activity). Scale bar = 50 μm.