Table 1 Ghent diagnostic criteria for Marfan's syndrome. Major Criteria needed in two organ systems and minor criterion in a third system.

System	Major criteria	Minor criteria
Family history	Independent diagnosis in parent, child or sibling	None
Genetics	Mutation FBN1	None
Cardiovascular	Aortic root dilatation, dissection of ascending aorta	Mitral valve prolapse, calcification of the mitral valve (<40 years), dilatation of the pulmonary artery, dilatation/dissection of descending aorta
Ocular	Ectopia lentis	2 needed of the following: flat cornea elongated globe myopia
Skeletal	At least 4 of the following: pectus excavatum needing surgery, pectus carinatum, pes planus, positive wrist or thumb sign, scoliosis >20° or spondylolisthesis, armspan‐height ratio >1.05, protrusio acetabulae, diminished extension elbows (<170°)	For the skeletal system to be involved 2–3 major, or 1 major and 2 minor signs should be present: moderate pectus excavatum, high arched palate, typical facial features, joint hypermobility
Pulmonary		Spontaneous pneumothorax, apical bulla
Skin		Striae, recurrent or incisional herniae
Central nervous system	Lumbosacral dural ectasia

Lumbosacral dural ectasia and protrusio acetabulae are diagnosed using magnetic resonance imaging or a computed tomography scan.