Figure 2 Radiograms of the lumbar spine, lateral projection of a girl with osteogenesis imperfecta type IV (patient no. 7) who, at the start of the treatment, had only compressions of the thoracic vertebrae. (A) Before start of treatment at 0.3 years of age. (B) After 3 years of treatment with increased mineralisation and vertebral height. Spondylolysis of the 5th lumbar vertebral arch was seen (arrow). (C) Two years after the end of treatment, lower mineral content was detected in the newly formed bone than in the older bone. The spondylolysis was healed.