Table 2 Median (and mean (SD)) values of serum alkaline phosphatase (μkat/l)), osteocalcin (μg/l), procollagen 1 carboxy‐terminal peptide (μg/l), collagen 1 teleopeptide (μg/l) and urine deoxypyridinoline/creatinine (nmol/mmol) before and during intravenous disodium pamidronate treatment and in untreated controls age matched to the latest recorded values.
| Patients | Controls | |||
|---|---|---|---|---|
| At start | After 2 years | Latest recorded | Before treatment | |
| ALP | 10.9 (11.1) | 6.3 (6.0)* | 6.0 (4.7)* | 9.4 (9.6)† |
| Osteocalcin | 46 (55) | 45 (52) | 42 (41) | 60 (57) |
| P1CP | 312 (381) | 100 (105)‡ | 88 (94)‡ | 98 (132) |
| 1CTP | 26 (27) | 14 (13)§ | 13 (13)§ | 10 (10) |
| u‐DPD/crea | 51.7 (49.3) | 26.2 (26.0) | 18.1 (19.4) | 150 (93.4) |
ALP, alkaline phosphatase; P1CP, procollagen 1 carboxy‐terminal peptide; 1CTP, collagen 1 teleopeptide; u‐DPD/crea, urine deoxypyridinoline.
*Significant change during treatment (p⩽0.001).
†When patient's latest recording values were compared with untreated controls, only alkaline phosphatase was found to be significantly lower (p⩽0.01).
‡Significant change during treatment (p⩽0.01).
§Significant change during treatment (p⩽0.04).