Figure 1.

I/LWEQ module sequence alignment. Alignment of the conserved C-terminal domain common to mouse (Mm) and C. elegans (Ce) talin, the Dictyostelium (Dd) talin homolog filopodin, the putative C. elegans Sla2 homolog, and S. cerevisiae (Sc) Sla2. The four conserved blocks, originally identified using the block maker program (34), are boxed; identities between all five sequences are highlighted by shading in the column, conservative substitutions are indicated by +. The most conserved positions (at least four out of five residues identical) are marked by a solid circle above the column. Block 1 contains 17% identities and 48% similarites; the values for blocks 2–4 are 63%/80%, 57%/83%, and 46%/66%, respectively.