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. Author manuscript; available in PMC: 2008 Sep 21.
Published in final edited form as: Neuroscience. 2007 Jul 17;148(4):978–995. doi: 10.1016/j.neuroscience.2007.07.013

Fig. 6.

Fig. 6

Changes in discharge rate (mean±standard error, imp/s) of striatal neurons following iv injections of cocaine HCl, cocaine methiodide and saline in rats during urethane anesthesia and in awake conditions with DA receptor blockade. n is the number of tested units (number of tests is shown in brackets). In awake conditions, the effect of time on discharge rate was significant for both COC HCl (F18,588=2.24; p<0.001) and COC-M (F9,309=4.21; p<0.001) but absent for saline (F11,371=0.83, p=0.72). In anesthetized conditions, the effect of time was significant for COC HCl (F37,1177=1.63, p<0.02) and COC-M (F13,433=2.39, p<0.01) but much smaller than in awake conditions. The effect was not significant for saline (F8,278=1.11, p=0.16). Filled symbols show values significantly higher than pre-injection baseline (mean for 10-s before the injection; hatched line).