Table 2.
Time Invariant Confounds | Time-Varying Confounds | Type I Error | Statistical Power | Coverage | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
x1 | x2 | x3 | x4 | x5 | x6 | x7 | x8 | α1 = 0 | α2 = .22 | α3 = .56 | α1 = 0 | α2 = .22 | α3 = .56 |
1.25 | 1.00 | 1.25 | 1.00 | 1.25 | 1.00 | 1.25 | 1.00 | 0.06 | 0.88 | 1.00 | 0.94 | 0.95 | 0.95 |
1.25 | 1.00 | 1.00 | 1.00 | 0.06 | 0.86 | 1.00 | 0.94 | 0.95 | 0.95 | ||||
1.00 | 1.25 | 1.00 | 1.00 | 0.06 | 0.87 | 1.00 | 0.94 | 0.95 | 0.95 | ||||
1.00 | 1.00 | 1.25 | 1.00 | 0.07 | 0.90 | 1.00 | 0.93 | 0.95 | 0.93 | ||||
1.00 | 1.00 | 1.00 | 1.25 | 0.05 | 0.88 | 1.00 | 0.95 | 0.94 | 0.95 | ||||
1.25 | 1.25 | 1.00 | 1.00 | 0.05 | 0.86 | 1.00 | 0.95 | 0.95 | 0.95 | ||||
1.00 | 1.00 | 1.25 | 1.25 | 0.07 | 0.91 | 1.00 | 0.93 | 0.94 | 0.92 | ||||
1.25 | 1.00 | 1.25 | 1.00 | 0.06 | 0.90 | 1.00 | 0.94 | 0.95 | 0.95 | ||||
1.00 | 1.25 | 1.00 | 1.25 | 0.05 | 0.87 | 1.00 | 0.95 | 0.94 | 0.94 | ||||
1.25 | 1.00 | 1.00 | 1.25 | 0.06 | 0.88 | 1.00 | 0.94 | 0.94 | 0.94 | ||||
1.00 | 1.25 | 1.25 | 1.00 | 0.05 | 0.91 | 1.00 | 0.95 | 0.95 | 0.93 | ||||
1.75 | 1.00 | 1.75 | 1.00 | 1.75 | 1.00 | 1.75 | 1.00 | 0.07 | 0.84 | 1.00 | 0.93 | 0.95 | 0.96 |
1.75 | 1.00 | 1.00 | 1.00 | 0.07 | 0.82 | 1.00 | 0.93 | 0.94 | 0.93 | ||||
1.00 | 1.75 | 1.00 | 1.00 | 0.06 | 0.83 | 1.00 | 0.94 | 0.94 | 0.94 | ||||
1.00 | 1.00 | 1.75 | 1.00 | 0.13 | 0.94 | 1.00 | 0.87 | 0.86 | 0.72 | ||||
1.00 | 1.00 | 1.00 | 1.75 | 0.09 | 0.87 | 1.00 | 0.91 | 0.92 | 0.91 | ||||
1.75 | 1.75 | 1.00 | 1.00 | 0.07 | 0.83 | 1.00 | 0.93 | 0.94 | 0.94 | ||||
1.00 | 1.00 | 1.75 | 1.75 | 0.18 | 0.96 | 1.00 | 0.82 | 0.77 | 0.53 | ||||
1.75 | 1.00 | 1.75 | 1.00 | 0.14 | 0.95 | 1.00 | 0.86 | 0.85 | 0.67 | ||||
1.00 | 1.75 | 1.00 | 1.75 | 0.08 | 0.85 | 1.00 | 0.92 | 0.91 | 0.89 | ||||
1.75 | 1.00 | 1.00 | 1.75 | 0.09 | 0.88 | 1.00 | 0.91 | 0.91 | 0.89 | ||||
1.00 | 1.75 | 1.75 | 1.00 | 0.16 | 0.92 | 1.00 | 0.84 | 0.83 | 0.69 |
Notes:
1) x1, x2, x5, and x6 are continuous variables
2) x3, x4, x7, and x8 are binary variables
3) x2, x4, x6, and x8 have been ignored in stratification
4) Treatment effects (αk) for dose k, are expressed in standard deviation units (i.e., effect size).