FIGURE 6.
Properties along the MFEP connecting the open- and closed-state conformations of AKE by using the PNM. (a) The normalized energy as a function of path length. The energies are normalized by the maximum value of the path. (b) The values of (do − d)/(do − dc) between residues 127 (LID region) and 194 (CORE domain) and between residues 55 (NMP-binding domain) and 169 (CORE domain) as a function of the normalized path length.