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. 2007 Aug 17;93(11):3733–3744. doi: 10.1529/biophysj.107.108993

FIGURE 3.

FIGURE 3

Best fit models for wild-type and mutant human IgG3s and IgG4s. In each case, the Fc domain (oblate ellipsoid) is displayed at the bottom linked by a bent hinge to the two Fab domains (prolate ellipsoids). The possible regions of the C1q-binding motif in the CH2 region of Fc are highlighted in white. (a) Model with a 6-6-24 hinge for wild-type IgG3. (b) Model with a 2-2-5 hinge index for IgG3m15, which has only 15 amino acids in the hinge region. (c) Model for the hingeless mutant IgG3 HM5 with a 4-4-0 hinge. (d) Model with a 2-2-2 hinge index for wild-type IgG4. (e) Model with a 3-3-3 hinge for the IgG4S331P mutant.