Table 1.
Characterization of chromosome fusion junctions in tert and atm tert by FISH
| Mutant | Line | Total anaphases counted | Total fusion events | Subtelomeric DNA at junction* |
|---|---|---|---|---|
| tert G6 | Ref. 32 | 3,414 | 174 | 2L: 30% |
| 3L: 30% | ||||
| 4L: 29% | ||||
| 3R: 15% | ||||
| 4R: 5% | ||||
| 1R: 4% | ||||
| 5L: 2% | ||||
| tert G6 | 69 | 1,258 | 39 | 2L or 4L: 5 (13%) Other: 34 (87%) |
| tert G8 | 69 | 208 | 72 | 2L or 4L: 35 (49%) Other: 53 (74%) |
| atm tert G5 | D5 | 157 | 45 | 2L or 4L: 0 1L: 28 (62%) Other: 0 |
| atm tert G5 | F11† | 92 | 27 | 4L: 27 (100%) |
| atm tert G5 | D3† | 76 | 17 | 2L: 17 (100%) |
*Percentages do not total 100% because junctions may be composed of two different chromosome ends.
†For atm tert lines F11 and D3, the involvement of 4L or 2L was determined by the presence or absence, respectively, of 5S rDNA at the junction (see Fig. 1).