Table 1.
Autoimmunity in B6.aire−/− mice treated with innate immune stimuli
| Treatment | Pathway | Clinical scores |
|---|---|---|
| Untreated | — | 3, 4, 4, 5, 6 |
| LPS | TLR-4 | 0, 3, 3, 5 |
| poly(I:C) | TLR-3 | 0, 4, 4, 4 |
| poly(I:C), rep | TLR-3 | 3, 5, 5 |
| CpG | TLR-9 | 2, 3, 4, 5, 6 |
| CpG, rep | TLR-9 | 5, 7, 8, 8 |
| poly(I:C) and CpG, rep | TLR-3 and TLR-9 | 4, 6 |
| Proteoglycan | TLR-2 | 5, 5 |
| PAM3CSK4 | TLR-2 | 1, 3, 5, 7 |
| Zymosan | TLR-2/dectin-1 | 6, 7 |
| β-1,3-glucan | Dectin-1 | 0, 2, 3, 4, 4 |
| Muramyl dipeptide | NOD-2 | 4, 5, 5, 7 |
| Anti-CD40 | CD40 | 2, 5, 6, 10 |
rep, repeated administrations. Infiltration was scored as outlined in Materials and Methods.