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. 2007 Nov 7;104(46):18205–18210. doi: 10.1073/pnas.0706953104

Fig. 1.

Fig. 1.

Neonatal hypoglycemia in MC2R KO mice. (A) Blood glucose levels on postnatal day 0.5 at 1200 hours. Detection limit was 20 mg/dl. Each point indicates the glucose level of a single pup. The blood glucose level of 12 of 14 homozygous pups was under detection level (<20 mg/dl). The values below detection level were plotted at 10 mg/dl. (B) MC2R pups were killed at 1200 hours, and liver RNAs were prepared. The experiments were performed with postnatal day 0.5 MC2R−/− (n = 6) and MC2R+/? (n = 9) mice. The expression of phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase), and peroxisome proliferator-activated receptor α (PPARa) in the liver was determined by qRT-PCR. Data are expressed as means ± SEM. Statistical significance was determined by t test. #, P < 0.05.