Skip to main content
. 2007 Nov 7;104(46):18286–18291. doi: 10.1073/pnas.0708611104

Fig. 2.

Fig. 2.

Tactile responses in CA1 depend on the integrity of the somatosensory lemniscal pathway. Muscimol (0.1%) was injected into S1 (A and D), VPM (B), or both (C), and the effects were measured on CA1 units after stimulation of the IO nerve. (A) The left histogram shows muscimol injection caused a great reduction on electrically evoked responses (mean ± SEM) of CA1 units (average of two cases). The right histogram shows the effects of muscimol on sampled units through the difference between average cell activity before and after the injection (red dashed line indicates no difference). (B) Injection of muscimol into the VPM disrupts tactile processing in S1 as expected but also causes a much stronger reduction in CA1 unit activity than inactivation of S1 only (compare with A). (C) Muscimol injection into both S1 and VPM brings about a complete reduction in CA1 unit activity. (D) Peristimulus time histograms of two representative units showing the effects of S1 inactivation on electrically evoked response in S1 and CA1. See Fig. 1 legend for description of peristimulus time histogram plots.