Table 1.

Physiological parameters in normal and diabetic rats following induction of Type 2 diabetes but preceding HK gene delivery

	Nondiabetic Normal Rats(n=16)		Diabetic Rats (n=32)
	Baseline	Week 8	Baseline	Week 8
Body weight (g)	216.1±14.8	258.7±20.1	214.9±15.7	233.6±17.9*
Systolic pressure (mmHg)	94.5±4.4	94.5±3.5	95±5.1	124.1±3.9*
Fasting glucose (mmol/L)	5.43±0.68	4.61±0.82	5.49±0.74	3.94±0.56
2h glucose (mmol/L)		6.77±1.02		15.66±2.41*
Fasting insulin (mlU/L)	2.92±0.72	3.44±0.88	2.81±0.82	10.12±2.47*
Triglycerides (mmol/L)	1.04±0.21	1.18±0.52	1.08±0.30	2.11±0.48*
Total cholesterol (mmol/L)	1.36±0.17	1.27±0.15	1.40±0.16	2.61±0.44*
HOMA IR	0.71±0.02	0.71±0.03	0.68±0.03	1.77±0.06*

Values are mean±SEM. Normal rats were fed with normal rat chow (Normal). Diabetic rats received streptozotocin injection and high fat diet (Diabetes). HOMA IR indicates homeostasis model assessment of insulin resistance.

^*P<0.05 vs. normal.