Table 2.

Physiological parameters in nondiabetic normal, diabetic-LacZ and diabetic-HK rats 12 weeks after introduction of rAAV-HK and rAAV-LacZ.

	nondiabetic normal	diabetic-HK	diabetic-LacZ
Weight (g)	285.7±11.2	253.2±9.7	242.5±8.1
Systolic pressure (mmHg)	97.5±3.8	98.5±5.5##	131.1±6.3**
Glucose (mmol/L)	5.51±0.79	13.09±3.01**	13.58±2.88**
Insulin (mIU/L)	3.56±0.69	8.19±2.45##	13.85±3.76**
HOMA IR	0.87±0.02	4.76±0.33##	8.36±0.48**
Triglyceride (mmol/L)	1.10±0.47	1.54±0.66##	2.38±0.89**
Total cholesterol (mmol/L)	1.36±0.55	1.48±0.62##	2.55±1.01**

Values are mean±SEM for 16 rats per group. Plasma glucose, insulin, triglyceride and total cholesterol were measured after an overnight fast at the end of experiment. Nondiabetic normal rats were injected with saline, diabetic rats were injected with rAAV·LacZ (LacZ) or rAAV·HK (HK). HOMA IR indicates homeostasis model assessment of insulin resistance.

^##P<0.01 vs. LacZ.

^**P<0.01 vs. Normal.