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. Author manuscript; available in PMC: 2008 Feb 17.
Published in final edited form as: Circ Res. 2007 Jul 5;101(4):420–428. doi: 10.1161/CIRCRESAHA.107.156463

Figure 7. Constriction is diminished in Abl-deficient arteries in response to activation with PE or KCl.

Figure 7

(A) Compared to untreated tissues or arteries producing luciferase shRNA (Luc RNA), PE-induced dose-response curve in arteries producing Abl shRNA was right shifted. Maximal contraction was also significantly reduced (n = 4-6). (B) The dose-response curve in response to KCl stimulation was right shifted with the reduced maximal response compared to untreated tissues or arteries producing Luc RNA. Constriction in response to PE or KCl is normalized to corresponding maximal levels in each artery before incubation (n = 5). Values are mean ± SE. Asterisk indicates significantly lower response as compared to untreated tissues or tissues generating Luc shRNA (P < 0.05).