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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: J Cereb Blood Flow Metab. 2007 Jan 10;27(7):1339–1351. doi: 10.1038/sj.jcbfm.9600440

Figure 2.

Figure 2

Effects of SCH23390, a D1 receptor antagonist, and sulpiride, a D2 receptor antagonist, on neuronal damage at 4 days of recovery and neurologic deficits in groups subjected to 40 mins of hypoxia and 7 mins of asphyxia (H–I). Hypoxic–ischemic or sham piglets were injected intravenous with saline, SCH23390, or sulpiride, either at 20 mins before hypoxia for pretreatment protocol, or at 5 mins of recovery for posttreatment protocol, followed by continuous infusion until 3 h of recovery. (A–F) Representative photographs of H&E-stained sections showing that pretreatment with SCH23390 or sulpiride partially alleviated ischemic neuronal damage in putamen of H–I piglets. Bar = 50 μm. (G) Quantitative results for viable putamen neurons expressed as a percent of the mean value in the sham group. (H) Neurologic score during the 4-day recovery. Data represent means±s.d. (n = 4 to 15 per group). *P < 0.05 versus sham group treated with saline; #P < 0.05 versus H–I group treated with saline; ANOVA followed by the Student–Newman–Keuls test.