Table 1.
Antitumor activity of BAT in nude and beige mice bearing B16 melanoma
| BAT treatment | No. of metastases
|
|||
|---|---|---|---|---|
| Exp. 1
|
Exp. 2
|
|||
| − | + | − | + | |
| Effect of BAT in nude mice | ||||
| C57BL | >200 | 0 | >200 | 1 ± 1 |
| Nude | >200 | 48 ± 25 | 95 ± 45 | 10 ± 3 |
| Effect of BAT in beige mice | ||||
| C57Bl | 141 ± 8 | 0 | 49 ± 8 | 0 |
| Beige | >200 | 47 ± 39 | 140 ± 47 | 101 ± 44 |
Mice were injected (i.v.) with B16 melanoma (5 × 104) cells and 14 days later with BAT (10 μg/mouse). Mice were sacrificed 24 days posttumor inoculation and the number of lung metastases were scored. More than 200 represents confluent tumor growth in the lungs. Five mice were used in each group in each experiment, and the results are expressed as mean ± SD.