Table 5.
BAT treatment at different times following human melanoma inoculation of SCID mice engrafted with human lymphocytes
| BAT treatment, day | No. metastases | Lung weight, mg |
|---|---|---|
| None | >250 | 750 ± 70 |
| 3 | 206 ± 75 | 665 ± 150 |
| 5 | 89 ± 7 | 315 ± 8 |
| 10 | 35 ± 12 | 219 ± 1 |
| 14 | 10 ± 17 | 217 ± 6 |
BAT was administered (10 μg/mouse) at different times in relation to tumor inoculation at day 0. Human PBMC were engrafted i.p. at 5 × 107/cells per mouse, 1 day postinjection of anti-GM1 (25 μg/mouse). Tumor cells were injected i.v. 3–5 days later at 7 × 105 cells/mouse. Twenty-four-day posttumor inoculation mice were sacrificed and the number of lung metastases and weights were determined. Average lung weight of untreated mice is 210 ± 10 mg.