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Kinetic parameters for TmTK substrates at 37°C & 82°C.
| substrate | KM (μM) | kcat (s−1) | kcat/KM × 104 (M−1 s−1) | relative efficiency | Hill coef. |
|---|---|---|---|---|---|
| T (37°C) | 0.5 ± 0.2 | 0.3 ± 0.08 | 60 | 1 | 0.98 |
| T (82°C) | 1.0 ± 0.15 | 3.5 ± 0.3 | 350 | 5.8 | 1.1 |
|
| |||||
| ATP (37°C) | 40 ± 12 | 0.4 ± 0.04 | 1.0 | 1 | 1.13 |
| ATP (82°C) | 187 ± 21(K0.5) | 3.5 ± 0.3 | 1.8 | 1.8 | 2.4 |
|
| |||||
| AZT (37°C) | 0.65 ± 0.2 | 0.29 ± 0.03 | 45 | 1 | - |
| AZT (82°C) | 8.7 ± 3 | 1.6 ± 0.29 | 18 | 0.4 | - |
