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. 2007 Jul;130(1):41–54. doi: 10.1085/jgp.200709770

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Conductance of the palytoxin-bound Na/K pump-channels in squid. (A) Outside-out patch from a giant fiber lobe neuron held at −40 mV with symmetrical 500 mM Na⁺. The patch showed no endogenous channel activity before the exposure to 50 pM palytoxin. After ∼12 s of exposure to palytoxin, the first Na/K pump-channel opened, immediately following which the toxin was removed. During toxin washout, a second pump-channel opened. (B) Current records acquired at holding potentials of −60, −70, and −80 mV are shown on the left and the corresponding current amplitude histograms on the right. Histograms were fitted with multiple-peak Gaussian functions (solid lines) to estimate the single-channel current amplitude at each potential. (C) Voltage dependence of the single-channel current. Solid line represents a least-squares straight line fit with a slope of 7.9 ± 0.6 pS.