. Author manuscript; available in PMC: 2008 Aug 1.

Published in final edited form as: Carcinogenesis. 2007 Apr 13;28(8):1665–1671. doi: 10.1093/carcin/bgm085

Table II.

Apparent Vmax and Km of SMZ and AcCoA for NAT2 allozymes expressed in COS-1 cells^a

NAT2 allozymes	Vmax^SMZ	Km^SMZ
NAT2 4	158 ± 34	601 ± 141
NAT2-191A	22.9 ± 10.7 ^*	643 ± 127
NAT2-282T	137 ± 14	583 ± 144
NAT2-341C	30.5 ± 11.7 ^*	673 ± 48
NAT2-481T	126 ± 28	708 ± 47
NAT2-499A	82.2 ± 10.2 ^*	765 ± 56
NAT2-590A	16.4 ± 2.6 ^*	529 ± 42
NAT2-803G	159 ± 31	550 ± 115
NAT2-857A	32.8 ± 3.3 ^*	74.2 ± 8.9 ^*
NAT2 5B	31.9 ± 5.9 ^*	640 ± 78
NAT2 6A	26.9 ± 7.9 ^*	480± 49
NAT2 7B	20.7 ± 4.5 ^*	90.7 ± 8.1 ^*
NAT2 14B	22.0 ± 4.0 ^*	778 ± 119
NAT2 allozymes	Vmax^AcCoA	Km^AcCoA

NAT2 4	123 ± 25	534 ± 37
NAT2-191A	17.9 ± 2.4 ^*	413 ± 47
NAT2-282T	104 ± 22	476± 8
NAT2-341C	29.9 ± 3.0 ^*	553 ± 47
NAT2-481T	94.0 ± 4.2	531 ± 22
NAT2-499A	55.8 ± 19.4 ^*	437 ± 71
NAT2-590A	12.9 ± 2.3 ^*	482± 35
NAT2-803G	119 ± 9	445 ± 52
NAT2-857A	57.5 ± 10.7 ^*	1280 ± 259 ^*
NAT2 5B	12.4 ± 2.4 ^*	430± 125
NAT2 6A	14.8 ± 2.3 ^*	577 ± 60
NAT2 7B	46.5 ± 9.0 ^*	1235 ± 92 ^*
NAT2 14B	12.5 ± 0.9 ^*	309 ± 81

COS-1 cells were transfected with NAT2 alleles possessing different SNPs or haplotypes in triplicate. The data represents the mean and standard deviation of three apparent Vmax (nmol/min/mg) or Km (micromolar) calculations determined independently.

: Significantly different from that of NAT2 4, p<0.05.