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ESR2 haplotype distribution by sex and disease status.
| Haplotype frequency (%) | P value* | |||||
|---|---|---|---|---|---|---|
| 1-1-1 † | 1-1-2 | 1-2-1 | 2-1-1 | 2-1-2 | ||
| Men | ||||||
| CVD cases | 0.19 | 0.35 | 0.03 | 0.41 | 0.02 | 0.62 |
| CVD controls | 0.19 | 0.35 | 0.03 | 0.40 | 0.03 | |
| Women | ||||||
| CVD cases | 0.24 | 0.29 | 0.00 | 0.32 | 0.13 | 0.07 |
| CVD controls | 0.25 | 0.30 | 0.02 | 0.30 | 0.12 | |
P-value for global likelihood ratio test
1 denotes major allele, 2 denotes minor allele at each site: rs1271572, rs1256049, rs4986938.
