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In the absence of Ii, expression of HLA-DM augments presentation by M1.DR1 to alloreactive T cell clones generated against allogeneic PBMC but inhibits presentation to clones raised against M1.DR1.B7. Mitomycin-C-treated APC, M1.DR1 (•), and M1.DR1.DM (⋄) were used as stimulators for alloreactive T cell clones (104 per well) raised against M1.DR1.B7 (A) or PBMC (B). The assays were as described in the legends of Figs. 3 and 4 and in the text. SEM were less than 10%.
